The NDC/HCPCS Crosswalk file provides a list of National Drug Codes (NDC) linked to Level II HCPCS codes, including pricing conversion factors for billable claims submitted to the DME MACs. This crosswalk enables the processing of claims using the NCPDP format. It includes prescription drugs administered in a home setting that are eligible for reimbursement under the DMEPOS benefit.
The PDAC updates the crosswalk monthly to add, revise, or delete NDCs as published in the RED BOOK drug compendium. The prepared NDC/HCPCS Crosswalk files below outline these updates and changes.
For NDC/HCPCS crosswalk questions, view our NDC/HCPCS Crosswalk FAQs and Definitions.
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May 2025
NDC to HCPCS Crosswalk (Excel, 1141 KB)
NDC to HCPCS Crosswalk (PDF, 2766 KB)
Date Changes (PDF, 14 KB)
Coding Changes (PDF, 9 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 29 KB)
Records and NDCs Removed (PDF, 13 KB)
Additional Changes (PDF, 9 KB)
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April 2025
NDC to HCPCS Crosswalk (Excel, 1142 KB)
NDC to HCPCS Crosswalk (PDF, 2759 KB)
Date Changes (PDF, 25 KB)
Coding Changes (PDF, 36 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 53 KB)
Records and NDCs Removed (PDF, 12 KB)
Additional Changes (PDF, 9 KB)
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March 2025
NDC to HCPCS Crosswalk (Excel, 1122 KB)
NDC to HCPCS Crosswalk (PDF, 2721 KB)
Date Changes (PDF, 17 KB)
Coding Changes (PDF, 9 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 24 KB)
Records and NDCs Removed (PDF, 13 KB)
Additional Changes (PDF, 9 KB)
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February 2025
NDC to HCPCS Crosswalk (Excel, 1119 KB)
NDC to HCPCS Crosswalk (PDF, 2714 KB)
Date Changes (PDF, 17 KB)
Coding Changes (PDF, 9 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 25 KB)
Records and NDCs Removed (PDF, 11 KB)
Additional Changes (PDF, 9 KB)
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January 2025
NDC to HCPCS Crosswalk (Excel, 1121 KB)
NDC to HCPCS Crosswalk (PDF, 2709 KB)
Date Changes (PDF, 19 KB)
Coding Changes (PDF, 45 KB)
Conversion Factor Changes (PDF, 10 KB)
Records and NDCs Added (PDF, 65 KB)
Records and NDCs Removed (PDF, 17 KB)
Additional Changes (PDF, 9 KB)
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